Analysis of Galleria mellonella hemolymph proteins profile after metalloproteinase immune challenge
نویسندگان
چکیده
منابع مشابه
Anti-Listeria activities of Galleria mellonella hemolymph proteins.
We report the use of antimicrobial hemolymph proteins from the model host Galleria mellonella as an inhibitor for various Listeria strains, providing a novel source for antilisterial therapeutics. We also have shown that specific virulence-associated genes known to mediate antimicrobial resistance of Listeria in mammalian models indicated a similar function in Galleria.
متن کاملThe effect of Galleria mellonella hemolymph polypeptides on Legionella gormanii.
Among Legionella species, which are recognized to be pathogenic for humans, L. gormanii is the second prevalent causative agent of community-acquired pneumonia after L. pneumophila. Anti-L. gormanii activity of Galleria mellonella hemolymph extract and apolipophorin III (apoLp-III) was examined. The extract and apoLp-III at the concentration 0.025 mg/ml caused 75% and 10% decrease of the bacter...
متن کاملEffect of Pseudomonas aeruginosa Elastase B on Level and Activity of Immune Proteins/Peptides of Galleria mellonella Hemolymph
Abstract Susceptibility of proteins and peptides present in immune hemolymph of Galleria mellonella Fabricius (Lepidoptera: Pyralidae) larvae to proteolytic degradation by purified elastase B of Pseudomonas aeruginosa was studied. Results showed that apoLp-III protein was gradually digested by elastase B in vitro. Additionally, polipeptides with molecular mass 6.5 and 4 kDa were degraded afte...
متن کاملPurification and characterization of eight peptides from Galleria mellonella immune hemolymph.
Defense peptides play a crucial role in insect innate immunity against invading pathogens. From the hemolymph of immune-challenged greater wax moth, Galleria mellonella (Gm) larvae, eight peptides were isolated and characterized. Purified Gm peptides differ considerably in amino acid sequences, isoelectric point values and antimicrobial activity spectrum. Five of them, Gm proline-rich peptide 2...
متن کاملNew to Galleria mellonella
EditoriAL Pathogens and their respective hosts interact closely leading to the host–pathogen framework response that could result in different outcomes that range from pathogen elimination to death of the host. To improve our ability to propose new measures that promote pathogen elimination and prevent host death, we need to have a comprehensive understanding of this interaction. Generally , mo...
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ژورنال
عنوان ژورنال: Annales UMCS, Biologia
سال: 2011
ISSN: 2083-3563,0066-2232
DOI: 10.2478/v10067-011-0024-2